A-190 The Effect of Lipemia on the Laboratory Assessment of Blood Gases

Abstract Background Unlike the electrolyte exclusion phenomenon, little is known about effects of lipemia on laboratory assessment total carbon dioxide (tCO2) and bicarbonate (HCO3−). Depending method used, lipemia-induced turbidity a specimen can impact outcome results. The photometric-enzymatic, rather than indirect ion selective more easily interfered with by turbid sample. Consequently, HCO3− tCO2 results from severely lipemic sample may be falsely diminished. A recent case report suggests an association between high lipids HCO3−. larger study to investigate this trend imperative guide medical practice, since preanalytical component accounts for approximately 68% all clinical errors. This aims analytical relationship blood gases analyses. Methodology Three months’ worth patient test totaling 660 data points were retrospectively extracted electronic health record filtered using excel spreadsheet. Data collected included triglycerides (TGs), cholesterol (tChol), HDL-Cholesterol as well (using enzymatic method), HCO3−, pH pCO2 both ambulatory in-patient setting. was analyzed spreadsheet GraphPad prism. Results 399 patients had TGs results, 372 tCO2, 162 simultaneously resulted. Of measurements, 79 lower reference interval 87 performed TGs, out which 22 low unextreme (<1000 mg/dL) pH; only 2 normal 1 (>1000 4 pH. All HDL-C measurements also TGs. 31 who above 1000 mg/dL, 20 while 11 recorded none tCO2; 3 and, no pH, > 4000 mg/dL. In 5 instances initial continually increased being serially resolved. Discussion Conclusion Overall, our shows inverse correlation extremely mg/dL in presence rules metabolic disturbance. Since chiefly represents HCO3-, setting TG, indicates acidosis. serial increase are resolved corroborates converse correlation. present demonstrates that resolution essential not accuracy electrolytes but improve interpretation blood-gas beneficial minimization interferences, quality improvement process management suspected abnormalities. future, expanded set interventional studies will explored further authenticate understanding.